ELISA analysis of phospho- and non phosho- immunogen peptide using GTX00973 MLKL (phospho Ser358) antibody. P-peptide : phospho-peptide N-peptide : non-phospho-peptide Peptides concentration : 1microg/ml
ELISA analysis of phospho- and non phosho- immunogen peptide using GTX00973 MLKL (phospho Ser358) antibody. P-peptide : phospho-peptide N-peptide : non-phospho-peptide Peptides concentration : 1microg/ml
MLKL (phospho Ser358) antibody - Orthogonal Validated
GTX00973
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMLKL
Overview
- SupplierGeneTex
- Product NameMLKL (phospho Ser358) antibody - Orthogonal Validated
- Delivery Days Customer9
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID197259
- Target nameMLKL
- Target descriptionmixed lineage kinase domain like pseudokinase
- Target synonymshMLKL; mixed lineage kinase domain-like protein
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionThis gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
- ReactivityHuman, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203
References
- Triclosan-induced neuroinflammation develops caspase-independent and TNF-alpha signaling pathway associated necroptosis in Neuro-2a cells. Katiyar P et al., 2022, Curr Res ToxicolRead more