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IHC-P analysis of mouse heart tissue using GTX00973 MLKL (phospho Ser358) antibody. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Dilution : 1:100
IHC-P analysis of mouse heart tissue using GTX00973 MLKL (phospho Ser358) antibody. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Dilution : 1:100
IHC-P analysis of mouse heart tissue using GTX00973 MLKL (phospho Ser358) antibody. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Dilution : 1:100

MLKL (phospho Ser358) antibody

GTX00973
GeneTex
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetMLKL
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Overview

  • Supplier
    GeneTex
  • Product Name
    MLKL (phospho Ser358) antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:2000. IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID197259
  • Target name
    MLKL
  • Target description
    mixed lineage kinase domain like pseudokinase
  • Target synonyms
    hMLKL, mixed lineage kinase domain-like protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ8NB16
  • Protein Name
    Mixed lineage kinase domain-like protein
  • Scientific Description
    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Ma Y, He F, Chen X, et al. Low-frequency pulsed electromagnetic fields alleviate the condylar cartilage degeneration and synovitis at the early stage of temporomandibular joint osteoarthritis. J Oral Rehabil. 2024,51(4):666-676. doi: 10.1111/joor.13636
    Read this paper
  • Katiyar P, Banerjee S, Nathani S, et al. Triclosan-induced neuroinflammation develops caspase-independent and TNF-α signaling pathway associated necroptosis in Neuro-2a cells. Curr Res Toxicol. 2022,3:100072. doi: 10.1016/j.crtox.2022.100072
    Read this paper

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