Paraformaldehyde fixed frozen section of adult rat cortex stained with GTX16208 in red and counterstained for DNA in blue. Note that GTX16208 stains neuronal nuclei and distal perikarya. These antibodies do not bind to the nuclei of perikarya of non-neuronal cells, so that they can be used to identify neurons.

NeuN antibody

GTX16208

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

DownloadDatasheet

Product group Antibodies

TargetRBFOX3

Overview

Supplier
GeneTex
Product Name
NeuN antibody
Delivery Days Customer
9
Application Supplier Note
WB:1:5,000-1:10,000. IF/IHC 1:500-1:1,000.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID146713
Target name
RBFOX3
Target description
RNA binding fox-1 homolog 3
Target synonyms
fox-1 homolog C; FOX3; FOX-3; hexaribonucleotide binding protein 3; HRNBP3; NEUN; neuN antigen; neuronal nuclei antigen; RNA binding protein fox-1 homolog 3; RNA binding protein, fox-1 homolog 3
Host
Rabbit
Isotype
IgG
Protein IDA6NFN3
Protein Name
RNA binding protein fox-1 homolog 3
Scientific Description
This gene encodes a member of the RNA-binding FOX protein family which is involved in the regulation of alternative splicing of pre-mRNA. The protein has an N-terminal proline-rich region, an RNA recognition motif (RRM) domain, and a C-terminal alanine-rich region. This gene produces the neuronal nuclei (NeuN) antigen that has been widely used as a marker for post-mitotic neurons. This gene has its highest expression in the central nervous system and plays a prominent role in neural tissue development and regulation of adult brain function. Mutations in this gene have been associated with numerous neurological disorders. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2017]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

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Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response. Manet C et al., 2022 Dec 20, J Neuroinflammation
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Therapeutic development for Canavan disease using patient iPSCs introduced with the wild-type ASPA gene. Chao J et al., 2022 Jun 17, iScience
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NeuN antibody

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Overview

References

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