Immunohistochemistry analysis of paraffin-embedded human lung cancer using p27 Polyclonal Antibody at dilution of 1:400.
Immunohistochemistry analysis of paraffin-embedded human lung cancer using p27 Polyclonal Antibody at dilution of 1:400.
p27 Polyclonal Antibody
E-AB-70373
Product group Antibodies
Overview
- SupplierElabscience
- Product Namep27 Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionThis gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).
- UNSPSC12352203