PAX6(PAX6/1166), 1mg/mL [26628-22-8]

Biotium

PAX6(PAX6/1166), 1mg/mL [26628-22-8]

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

26628-22-8

Research Use Only

Monoclonal

PAX6/1166

1 mg/ml

PAX6

paired box 6

AN, AN1, AN2, ASGD5, D11S812E, FVH1, MGDA, WAGR, paired box protein Pax-6, Aniridia 1, Aniridia 2, alternative protein PAX6, aniridia type II protein, oculorhombin, paired box 6 PAX6-12a isoform, paired box 6 PAX6A-ASdel6 isoform, paired box 6 PAX6A-ASdel6-AS7 isoform, paired box 6 PAX6A-del6 isoform, paired box 6 PAX6B-ASdel6 isoform, paired box 6 PAX6D isoform, paired box homeotic gene-6

Mouse

IgG1

Paired box protein Pax-6

Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human, Mouse

-20°C

41116161