PD1 / PDCD1 / CD279(PDCD1/922), 1mg/mL [26628-22-8]

Biotium

PD1 / PDCD1 / CD279(PDCD1/922), 1mg/mL [26628-22-8]

9

Flow Cytometry, ImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

26628-22-8

Research Use Only

Monoclonal

PDCD1/922

1 mg/ml

PDCD1

programmed cell death 1

ADMIO4, AIMTBS, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1, programmed cell death protein 1, programmed cell death 1 protein, protein PD-1, systemic lupus erythematosus susceptibility 2

Mouse

IgG1

Programmed cell death protein 1

PD-1 (also known as Programmed Death 1, CD279, and PDCD1) is a negative regulatory T cell surface receptor. PD-1 is a Type I transmembrane protein expressed on the plasma membrane of T-cells. It is a T-cell checkpoint protein, involved in preventing autoimmunity. Because binding of PD-1 by its ligands PD-L1 or PD-L2 has a suppressive effect on the immune system, inhibition of the PD-1/PD-L1 pathway is a major strategy of immune-oncology therapies. PD-L1 is upregulated in certain cancers, and blocking PD-1 or PD-L1 can inhibit cancer growth. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human, Mouse

-20°C

41116161