Presenilin 1 antibody [24-4B5]

GeneTex

Presenilin 1 antibody [24-4B5]

9

Recommended Starting Dilutions:For WB: Use at 1:500For IHC: Use at 1:200Not yet tested in other applications. Optimal dilutions should be determined experimentally by the researcher.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

24-4B5

1 mg/ml

Unconjugated

PSEN1

presenilin 1

ACNINV3; AD3; FAD; presenilin-1; PS1; PS-1; S182

Rat

IgG1

Presenilin-1

Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203