Presenilin 1 antibody [APS 11]

GeneTex

Presenilin 1 antibody [APS 11]

9

WB: 1:100-1:1000. ICC/IF: 0.75 microg/ml. IHC-P: 0.75 microg/ml. ELISA: 4.5 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

APS 11

1 mg/ml

Unconjugated

PSEN1

presenilin 1

ACNINV3, AD3, CMD1U, FAD, PS-1, PS1, PSNL1, S182, presenilin-1, familial Alzheimer Disease

Mouse

IgG1

Presenilin-1

Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

-20°C or -80°C,2°C to 8°C

12352203