IHC-P analysis of human liver tissue using GTX15458 Presenilin 1 antibody [APS 18]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:200
![IHC-P analysis of human tonsil tissue using GTX15458 Presenilin 1 antibody [APS 18]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:20](https://www.genetex.com/upload/website/prouct_img/normal/GTX15458/GTX15458_1016_IHC-P_w_23060620_406.webp "IHC-P analysis of human tonsil tissue using GTX15458 Presenilin 1 antibody [APS 18]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:20")
![WB analysis of 20 ug of THP-1 cell lysate using GTX15458 Presenilin 1 antibody [APS 18]. Dilution : 1:250](https://www.genetex.com/upload/website/prouct_img/normal/GTX15458/GTX15458_1494_WB_w_23060620_951.webp "WB analysis of 20 ug of THP-1 cell lysate using GTX15458 Presenilin 1 antibody [APS 18]. Dilution : 1:250")
![ICC/IF analysis of mouse fibroblasts using GTX15458 Presenilin 1 antibody [APS 18].](https://www.genetex.com/upload/website/prouct_img/normal/GTX15458/GTX15458_255_ICC-IF_w_23060620_977.webp "ICC/IF analysis of mouse fibroblasts using GTX15458 Presenilin 1 antibody [APS 18].")
![ICC/IF analysis of MCF-7 cells using GTX15458 Presenilin 1 antibody [APS 18]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15458/GTX15458_256_ICC-IF_w_23060620_123.webp "ICC/IF analysis of MCF-7 cells using GTX15458 Presenilin 1 antibody [APS 18]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC")
![ICC/IF analysis of A2058 Cells using GTX15458 Presenilin 1 antibody [APS 18]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15458/GTX15458_257_ICC-IF_w_23060620_442.webp "ICC/IF analysis of A2058 Cells using GTX15458 Presenilin 1 antibody [APS 18]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC")
![ICC/IF analysis of HeLa cells using GTX15458 Presenilin 1 antibody [APS 18]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC](https://www.genetex.com/upload/website/prouct_img/normal/GTX15458/GTX15458_258_ICC-IF_w_23060620_479.webp "ICC/IF analysis of HeLa cells using GTX15458 Presenilin 1 antibody [APS 18]. Cells were probed without (right) or with(left) an antibody. Green : Primary antibody Blue : Nuclei Red : Actin Fixation : formaldehyde Dilution : 1:100 overnight at 4 oC")
IHC-P analysis of human liver tissue using GTX15458 Presenilin 1 antibody [APS 18]. Left : Primary antibody Right : Negative control without primary antibody Antigen retrieval : heat induced antigen retrieval was performed using 10mM sodium citrate (pH6.0) buffer, microwaved for 8-15 minutes Dilution : 1:200
Presenilin 1 antibody [APS 18]
GTX15458
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Primate, Rat
TargetPSEN1
Overview
- SupplierGeneTex
- Product NamePresenilin 1 antibody [APS 18]
- Delivery Days Customer9
- Antibody SpecificityNo cross-reactivity is seen with presenilin 2. This antibody detects an ~18 kDa protein representing PS1 CT (C-terminus fragment) and the ~46 kDa full-length PS1 from transfected SH-SY5Y cells.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDAPS 18
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID5663
- Target namePSEN1
- Target descriptionpresenilin 1
- Target synonymsACNINV3; AD3; FAD; presenilin-1; PS1; PS-1; S182
- HostMouse
- IsotypeIgG1
- Scientific DescriptionAlzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
- ReactivityHuman, Mouse, Primate, Rat
- Storage Instruction2°C to 8°C,-20°C or -80°C
- UNSPSC12352203