Presenilin 1 antibody

GeneTex

Presenilin 1 antibody

9

Amino acid sequence 14-33 of human presenilin-1 protein.

WB: 1:1,000. IHC-P: 1:100. IHC-Fr: 1:1,000. ELISA: 1:5,000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

Unconjugated

PSEN1

presenilin 1

ACNINV3; AD3; FAD; presenilin-1; PS1; PS-1; S182

Goat

IgG

Presenilin-1

Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Human

-20°C or -80°C,2°C to 8°C

12352203