RBFOX3 Polyclonal Antibody

Reddot Biotech

RBFOX3 Polyclonal Antibody

5

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.1 mg/ml

Unconjugated

RBFOX3

RNA binding fox-1 homolog 3

fox-1 homolog C; FOX3; FOX-3; hexaribonucleotide binding protein 3; HRNBP3; NEUN; neuN antigen; neuronal nuclei antigen; RNA binding protein fox-1 homolog 3; RNA binding protein, fox-1 homolog 3

Rabbit

IgG

Immunoprecipitation and mass spectrometry of the two major NeuN species at 45,Aei50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.

Human, Mouse

-20°C

12352203