Aloesin [30861-27-9]

Name: Aloesin [30861-27-9]
SKU: AG-CN2-0437_A27
Availability: BackOrder

AG-CN2-0437

CAS Number30861-27-9

Product group Chemicals

Estimated Purity>98%

Molecular Weight394.4

Overview

Supplier
AdipoGen Life Sciences
Product Name
Aloesin
Delivery Days Customer
10
CAS Number
30861-27-9
Certification
Research Use Only
Estimated Purity
>98%
Molecular Formula
C19H22O9
Molecular Weight
394.4
Scientific Description
C-glycosylated chromone compound. Tyrosinase inhibitor. Inhibits melanin production. Inhibitor of hyperpigmentation. Antioxidant. Free radical scavenger. Anti-inflammatory compound. Shown to up-regulate cyclin E/CDK2 kinase activity. Hepatoprotective. Stimulates cell proliferation. Anti-diabetic. Increased adiponectin production and improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice. - Chemical. CAS: 30861-27-9. Formula: C19H22O9. MW: 394.4. Isolated from Aloe vera. C-glycosylated chromone compound. Tyrosinase inhibitor. Inhibits melanin production. Inhibitor of hyperpigmentation. Antioxidant. Free radical scavenger. Anti-inflammatory compound. Shown to up-regulate cyclin E/CDK2 kinase activity. Hepatoprotective. Stimulates cell proliferation. Anti-diabetic. Increased adiponectin production and improves the insulin sensitivity in db/db and diet-induced obese-diabetic mice.
SMILES
CC(=O)CC1=CC(=O)C2=C(C)C=C(O)C([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2O1
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352200

Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997)
Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002)
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002)
Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002)
Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005)
Antitumor properties and modulation of antioxidant enzymes' activity by Aloe vera leaf active principles isolated via supercritical carbon dioxide extraction: H.A. El-Shemy, et al.; Curr. Med. Chem. 17, 129 (2010)
UP780, a chromone-enriched aloe composition improves insulin sensitivity: M. Yimam, et al.; Metab. Syndr. Relat. Disord. 11, 267 (2013)
Blood glucose lowering activity of aloe based composition, UP780, in alloxan induced insulin dependent mouse diabetes model: M. Yimam, et al.; Diabetol. Metab. Syndr. 6, 61 (2014)
Phytochemical constituents and in vitro radical scavenging activity of different Aloe species: L. Pucini, et al.; Food Chem. 170, 501 (2014)