The data was published in the journal Oncotarget in 2017. PMID: 27845893
![IHC analysis of the cortical Lewy body using alpha Synuclein antibody [4B12].](https://www.genetex.com/upload/website/prouct_img/normal/GTX21904/GTX21904_IHC_w_23060620_396.webp "IHC analysis of the cortical Lewy body using alpha Synuclein antibody [4B12].")
The data was published in the journal Oncotarget in 2017. PMID: 27845893
alpha Synuclein antibody [4B12]
GTX21904
ApplicationsDot Blot, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetSNCA
Overview
- SupplierGeneTex
- Product Namealpha Synuclein antibody [4B12]
- Delivery Days Customer9
- Application Supplier NoteDot: Use at a dilution of 1/100 - 1/10000. ELISA: Use at an assay dependent dilution. IHC-P: Use at a dilution of 1/100 - 1/1000. Antigen retrieval is not essential but may optimise staining. IHC-Fr: Use at a dilution of 1/100 - 1/1000. WB: Use at a dilution of 1/100 - 1/10000. Predicted molecular weight: 16 kDa. Optimal dilutions/concentrations should be determined by the end user.
- ApplicationsDot Blot, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID4B12
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6622
- Target nameSNCA
- Target descriptionsynuclein alpha
- Target synonymsNACP, PARK1, PARK4, PD1, alpha-synuclein, I+/--synuclein, non A-beta component of AD amyloid, synuclein alpha-140, synuclein, alpha (non A4 component of amyloid precursor)
- HostMouse
- IsotypeIgG1
- Protein IDP37840
- Protein NameAlpha-synuclein
- Scientific DescriptionAlpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Guo Q, Kawahata I, Jia W, et al. α-Synuclein decoy peptide protects mice against α-synuclein-induced memory loss. CNS Neurosci Ther. 2023,29(6):1547-1560. doi: 10.1111/cns.14120Read this paper
- Cheng A, Wang YF, Shinoda Y, et al. Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress. Acta Pharmacol Sin. 2022,43(3):552-562. doi: 10.1038/s41401-021-00675-8Read this paper
- Lemos M, Venezia S, Refolo V, et al. Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance. Transl Neurodegener. 2020,9(1):38. doi: 10.1186/s40035-020-00217-yRead this paper
- Heras-Garvin A, Refolo V, Reindl M, et al. High-salt diet does not boost neuroinflammation and neurodegeneration in a model of α-synucleinopathy. J Neuroinflammation. 2020,17(1):35. doi: 10.1186/s12974-020-1714-yRead this paper
- Refolo V, Bez F, Polissidis A, et al. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies. Acta Neuropathol Commun. 2018,6(1):2. doi: 10.1186/s40478-017-0504-yRead this paper
- Karampetsou M, Ardah MT, Semitekolou M, et al. Phosphorylated exogenous alpha-synuclein fibrils exacerbate pathology and induce neuronal dysfunction in mice. Sci Rep. 2017,7(1):16533. doi: 10.1038/s41598-017-15813-8Read this paper
- Venezia S, Refolo V, Polissidis A, et al. Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy. Mol Neurodegener. 2017,12(1):52. doi: 10.1186/s13024-017-0195-7Read this paper
- Pampalakis G, Sykioti VS, Ximerakis M, et al. KLK6 proteolysis is implicated in the turnover and uptake of extracellular alpha-synuclein species. Oncotarget. 2017,8(9):14502-14515. doi: 10.18632/oncotarget.13264Read this paper
- Emmanouilidou E, Minakaki G, Keramioti MV, et al. GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum. Brain. 2016,139(Pt 3):871-90. doi: 10.1093/brain/awv403Read this paper
- Helwig M, Klinkenberg M, Rusconi R, et al. Brain propagation of transduced α-synuclein involves non-fibrillar protein species and is enhanced in α-synuclein null mice. Brain. 2016,139(Pt 3):856-70. doi: 10.1093/brain/awv376Read this paper
Datasheet
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![IHC-P analysis of human brain, Lewy body dementia using GTX01946 alpha Synuclein antibody [KM51]. Note staining of alpha-synuclein-containing Lewy bodies.](https://www.genetex.com/upload/website/prouct_img/normal/GTX01946/GTX01946_20200811_IHC-P_92_w_23053121_721.webp)
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