Anti-IL-2 [UFKA-20]

Absolute Antibody

Anti-IL-2 [UFKA-20]

7

This antibody binds human IL-2. In particular, the antibody binds IL-2 dorsolaterally, with an angle of 55° counterclockwise to the vertical axis, contacting the C- and B-helices of IL-2 and thereby forming a clamp around the C-helix. The antibody engages

This antibody binds to Interleukin-2, a protein produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/UFKA-20 complex shows an improved selectivity towards regulatory T cells compared to IL-2 alone. IL-2/UFKA-20 can recognize the receptor IL of regulatory T cells on the base of the presence of CD25, therefore called CD25 bias. IL-2/UFKA-20 complex is able to efficiently stimulate CD25+ Treg cells in mice and rhesus macaques in vivo as well as in humans ex vivo.

Flow Cytometry, ELISA

ELISA; FC

Research Use Only

Monoclonal

UFKA-20

IL2

interleukin 2

aldesleukin; IL-2; interleukin-2; involved in regulation of T-cell clonal expansion; lymphokine; T cell growth factor; TCGF

Mouse

IgG2b

Interleukin-2

This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format for improved compatibility with existing reagents assays and techniques.

Human

Human

The original antibody was generated immunizing Balb/c mice with human IL-2.

-20°C,2°C to 8°C

12352203