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Ataxin 3 antibody

Research Use Only
GTX115032
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Zebra Fish
TargetATXN3
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Overview

  • Supplier
    GeneTex
  • Product Name
    Ataxin 3 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.36 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID4287
  • Target name
    ATXN3
  • Target description
    ataxin 3
  • Target synonyms
    AT3; ataxin-3; ATX3; JOS; josephin; Machado-Joseph disease protein 1; MJD; MJD1; olivopontocerebellar ataxia 3; SCA3; spinocerebellar ataxia type 3 protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP54252
  • Protein Name
    Ataxin-3
  • Scientific Description
    Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chip Protein U-Box Domain Truncation Affects Purkinje Neuron Morphology and Leads to Behavioral Changes in Zebrafish. Pakdaman Y et al., 2021, Front Mol Neurosci
    Read more
  • The Truncated C-terminal Fragment of Mutant ATXN3 Disrupts Mitochondria Dynamics in Spinocerebellar Ataxia Type 3 Models. Hsu JY et al., 2017, Front Mol Neurosci
    Read more
  • Ataxin-3 expression correlates with the clinicopathologic features of gastric cancer. Zeng LX et al., 2014, Int J Clin Exp Med
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  • Amniotic fluid proteome analysis from Down syndrome pregnancies for biomarker discovery. Cho CK et al., 2010 Jul 2, J Proteome Res
    Read more