ProductsBack/Caspase 3 antibody [C33]

WB analysis of HeLa cells treated with camptothecin (2microM) lysate using GTX59551 Caspase 3 antibody [C33].

Caspase 3 antibody [C33]

Name: Caspase 3 antibody [C33]
SKU: GTX59551_G10
Availability: BackOrder

GTX59551

ApplicationsWestern Blot

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetCASP3

Overview

Supplier
GeneTex
Product Name
Caspase 3 antibody [C33]
Delivery Days Customer
9
Application Supplier Note
WB: 0.5-4 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
C33
Concentration
0.2 mg/ml
Conjugate
Unconjugated
Gene ID836
Target name
CASP3
Target description
caspase 3
Target synonyms
CPP32, CPP32B, SCA-1, caspase-3, CASP-3, CPP-32, PARP cleavage protease, SREBP cleavage activity 1, apopain, caspase 3, apoptosis-related cysteine peptidase, caspase 3, apoptosis-related cysteine protease, cysteine protease CPP32, procaspase3, protein Yama
Host
Mouse
Isotype
IgG1
Protein IDP42574
Protein Name
Caspase-3
Scientific Description
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. [provided by RefSeq, Aug 2017]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Salaroglio IC, Gazzano E, Abdullrahman A, et al. Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer. J Exp Clin Cancer Res. 2018,37(1):286. doi: 10.1186/s13046-018-0967-0
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Salaroglio IC, Mujumdar P, Annovazzi L, et al. Carbonic Anhydrase XII Inhibitors Overcome P-Glycoprotein-Mediated Resistance to Temozolomide in Glioblastoma. Mol Cancer Ther. 2018,17(12):2598-2609. doi: 10.1158/1535-7163.MCT-18-0533
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Pinzón-Daza ML, Salaroglio IC, Kopecka J, et al. The cross-talk between canonical and non-canonical Wnt-dependent pathways regulates P-glycoprotein expression in human blood-brain barrier cells. J Cereb Blood Flow Metab. 2014,34(8):1258-69. doi: 10.1038/jcbfm.2014.100
Read this paper