Caspase 3 antibody
GTX73090
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rabbit, Rat
TargetCASP3
Overview
- SupplierGeneTex
- Product NameCaspase 3 antibody - Orthogonal Validated
- Delivery Days Customer9
- Application Supplier NoteFor IHC-P: Use at a dilution of 1:1,000. For IP: Use at a dilution of 1:2,000. For WB: Use at a dilution of 1:500. Optimal dilutions/concentrations should be determined by the researcher.
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID836
- Target nameCASP3
- Target descriptioncaspase 3
- Target synonymsapopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP32; CPP-32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1
- HostRabbit
- IsotypeIgG
- Protein IDP42574
- Protein NameCaspase-3
- Scientific DescriptionThe protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. [provided by RefSeq, Aug 2017]
- ReactivityHuman, Mouse, Rabbit, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus. Saat N et al., 2019 Oct, Biotech HistochemRead more
- Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression. Wu KJ et al., 2012, Evid Based Complement Alternat MedRead more
- Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats. Firat U et al., 2012, Exp Diabetes ResRead more