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Caspase 3 antibody

Research Use Only
GTX73090
GeneTex
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rabbit, Rat
TargetCASP3
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Overview

  • Supplier
    GeneTex
  • Product Name
    Caspase 3 antibody - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    For IHC-P: Use at a dilution of 1:1,000. For IP: Use at a dilution of 1:2,000. For WB: Use at a dilution of 1:500. Optimal dilutions/concentrations should be determined by the researcher.
  • Applications
    ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID836
  • Target name
    CASP3
  • Target description
    caspase 3
  • Target synonyms
    apopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP32; CPP-32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP42574
  • Protein Name
    Caspase-3
  • Scientific Description
    The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. [provided by RefSeq, Aug 2017]
  • Reactivity
    Human, Mouse, Rabbit, Rat
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus. Saat N et al., 2019 Oct, Biotech Histochem
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  • Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression. Wu KJ et al., 2012, Evid Based Complement Alternat Med
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  • Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats. Firat U et al., 2012, Exp Diabetes Res
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