ICC/IF analysis of human primary fibroblasts using GTX28219 CD63 antibody [MEM-259]. Green : Primary antibody Red : Actin Blue : DAPI
![ICC/IF analysis of HeLa cells using GTX28219 CD63 antibody [MEM-259]. Green : Primary antibody Red : Actin Blue : DAPI](https://www.genetex.com/upload/website/prouct_img/normal/GTX28219/GTX28219_20191025_AP_002_213_w_23060722_894.webp "ICC/IF analysis of HeLa cells using GTX28219 CD63 antibody [MEM-259]. Green : Primary antibody Red : Actin Blue : DAPI")
![ICC/IF analysis of human skin fibroblasts using GTX28219 CD63 antibody [MEM-259]. Green : Primary antibody Red : Transferrin Blue : DAPI](https://www.genetex.com/upload/website/prouct_img/normal/GTX28219/GTX28219_20191025_AP_002_215_w_23060722_830.webp "ICC/IF analysis of human skin fibroblasts using GTX28219 CD63 antibody [MEM-259]. Green : Primary antibody Red : Transferrin Blue : DAPI")
![FACS analysis of IgE-activated peripheral blood using GTX28219 CD63 antibody [MEM-259].](https://www.genetex.com/upload/website/prouct_img/normal/GTX28219/GTX28219_20191025_AP_006_212_w_23060722_463.webp "FACS analysis of IgE-activated peripheral blood using GTX28219 CD63 antibody [MEM-259].")
ICC/IF analysis of human primary fibroblasts using GTX28219 CD63 antibody [MEM-259]. Green : Primary antibody Red : Actin Blue : DAPI
CD63 antibody [MEM-259]
GTX28219
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCD63
Overview
- SupplierGeneTex
- Product NameCD63 antibody [MEM-259]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:1000. ICC/IF: 10 microg/ml. IHC-P: 10 microg/ml. FACS: 2 microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMEM-259
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID967
- Target nameCD63
- Target descriptionCD63 molecule
- Target synonymsAD1, HOP-26, ME491, MLA1, OMA81H, Pltgp40, TSPAN30, CD63 antigen, AD1 antigen, CD63 antigen (melanoma 1 antigen), granulophysin, limp1, melanoma-associated antigen ME491, melanoma-associated antigen MLA1, ocular melanoma-associated antigen, tetraspanin-30, tspan-30
- HostMouse
- IsotypeIgG1
- Protein IDP08962
- Protein NameCD63 antigen
- Scientific DescriptionThe protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Lin SJ, Lin MC, Liu TJ, et al. Endosomal Arl4A attenuates EGFR degradation by binding to the ESCRT-II component VPS36. Nat Commun. 2023,14(1):7859. doi: 10.1038/s41467-023-42979-9Read this paper
- Lanna A, Vaz B, D'Ambra C, et al. An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory. Nat Cell Biol. 2022,24(10):1461-1474. doi: 10.1038/s41556-022-00991-zRead this paper
- Zhang C, Chong X, Jiang F, et al. Plasma extracellular vesicle derived protein profile predicting and monitoring immunotherapeutic outcomes of gastric cancer. J Extracell Vesicles. 2022,11(4):e12209. doi: 10.1002/jev2.12209Read this paper
- Lenzini S, Debnath K, Joshi JC, et al. Cell-Matrix Interactions Regulate Functional Extracellular Vesicle Secretion from Mesenchymal Stromal Cells. ACS Nano. 2021,15(11):17439-17452. doi: 10.1021/acsnano.1c03231Read this paper
- Peng X, Li X, Yang S, et al. LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation. J Exp Clin Cancer Res. 2021,40(1):183. doi: 10.1186/s13046-021-01990-yRead this paper
- Peng X, Yang L, Ma Y, et al. IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells. Biochim Biophys Acta Mol Cell Res. 2021,1868(1):118857. doi: 10.1016/j.bbamcr.2020.118857Read this paper
- Yang L, Peng X, Li Y, et al. Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma. Mol Cancer. 2019,18(1):78. doi: 10.1186/s12943-019-0990-6Read this paper
- Raulf N, Lucarelli P, Thavaraj S, et al. Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers. Eur J Cancer. 2018,102:52-68. doi: 10.1016/j.ejca.2018.07.123Read this paper
- Jakhria T, Hellewell AL, Porter MY, et al. β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes. J Biol Chem. 2014,289(52):35781-94. doi: 10.1074/jbc.M114.586222Read this paper
- Schmidt H, Gelhaus C, Lucius R, et al. Enrichment and analysis of secretory lysosomes from lymphocyte populations. BMC Immunol. 2009,10:41. doi: 10.1186/1471-2172-10-41Read this paper
Datasheet
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