Western blot analysis of extracts from Hela, 293 and 3T3 cells using IKK a(Ab-23) Antibody.
Western blot analysis of extracts from Hela, 293 and 3T3 cells using IKK a(Ab-23) Antibody.
CHUK (Ab-23) Antibody
CSB-PA904221
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCHUK
Overview
- SupplierCusabio
- Product NameCHUK (Ab-23) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1147
- Target nameCHUK
- Target descriptioncomponent of inhibitor of nuclear factor kappa B kinase complex
- Target synonymsBPS2; conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; I-kappa-B kinase-alpha; IkB kinase alpha subunit; IKBKA; IKK1; IKKA; IKK-a kinase; IKK-alpha; inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; Nuclear factor NFkappaB inhibitor kinase alpha; TCF16; TCF-16; transcription factor 16
- HostRabbit
- IsotypeIgG
- Protein IDO15111
- Protein NameInhibitor of nuclear factor kappa-B kinase subunit alpha
- Scientific DescriptionActs as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates Ser-10 of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines. Yuan ZQ, et al.(2002)J Biol Chem; 277(33): 29973-82. Ozes ON, et al. (1999)Nature; 401(6748): 82-5.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203