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ProductsBack/eIF2 alpha (phospho Ser52) antibody
GTX24837 ICC/IF Image
GTX24837 ICC/IF Image
GTX24837 ICC/IF Image

eIF2 alpha (phospho Ser52) antibody

Research Use Only
GTX24837
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityC. Elegans, Chicken, Drosophila, Feline, Human, Mouse, Primate, Rat, Yeast
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Overview

  • Supplier
    GeneTex
  • Product Name
    eIF2 alpha (phospho Ser52) antibody
  • Delivery Days Customer
    10
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Host
    Rabbit
  • Isotype
    IgG
  • Modification Type
    Phosphorylated
  • Scientific Description
    The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
  • Reactivity
    C. Elegans, Chicken, Drosophila, Feline, Human, Mouse, Primate, Rat, Yeast
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. Jorgensen E et al., 2008 Aug 11, BMC Cancer
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