ProductsBack/eIF2 alpha (phospho Ser51) antibody

Rabbit anti EIF2alpha [pS51] phosphospecific polyclonal antibody. Left: Image shows immunocytochemical analysis of EIF2alpha [pS51] in rat brain (mediodorsal neocortex) sections following traumatic axonal injury (TAI) (24 h). Control (prior to injury induction) shows low basal levels of EIF2alpha [pS51]. Right: Image shows double labeling of APP (red) and EIF2alpha [pS51] (green) in neurons subjected to traumatic axonal injury (TAI). Inset (above): higher magnification of neuronal soma with TAI. EIF2alpha [pS51] immunofluorescence is localized in cytoplasm of neuronal cell body.

eIF2 alpha (phospho Ser51) antibody

GTX24837

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

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Product group Antibodies

TargetEIF2S1

Overview

Supplier
GeneTex
Product Name
eIF2 alpha (phospho Ser52) antibody
Delivery Days Customer
9
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Conjugate
Unconjugated
Gene ID1965
Target name
EIF2S1
Target description
eukaryotic translation initiation factor 2 subunit alpha
Target synonyms
EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; eIF-2-alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Host
Rabbit
Isotype
IgG
Protein IDP05198
Protein Name
Eukaryotic translation initiation factor 2 subunit 1
Scientific Description
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response. Yildirim AD et al., 2022 Oct, J Lipid Res
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Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. Jorgensen E et al., 2008 Aug 11, BMC Cancer
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eIF2 alpha (phospho Ser51) antibody

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Overview

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