Hec1 antibody [9G3.23]
GTX70268
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
Product group Antibodies
ReactivityHamster, Human, Mammals, Mouse
TargetNDC80
Overview
- SupplierGeneTex
- Product NameHec1 antibody [9G3.23]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID9G3.23
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID10403
- Target nameNDC80
- Target descriptionNDC80 kinetochore complex component
- Target synonymsHEC; HEC1; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; retinoblastoma-associated protein HEC; TID3
- HostMouse
- IsotypeIgG2a
- Protein IDO14777
- Protein NameKinetochore protein NDC80 homolog
- Scientific DescriptionThis gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
- ReactivityHamster, Human, Mammals, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression. Hong J et al., 2022 May, J Ginseng ResRead more
- Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Solon AL et al., 2021 Nov 19, Sci AdvRead more
- Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins. Steblyanko Y et al., 2020 Dec 1, EMBO JRead more
- Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Yoshida S et al., 2020 May 27, Nat CommunRead more
- Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy. Chuang SH et al., 2020 Apr 1, Eur J Med ChemRead more
- Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells. Broad AJ et al., 2020 Mar 2, J Cell BiolRead more
- PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation. Kim S et al., 2020 Jan 30, Nat CommunRead more
- Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation. Liang C et al., 2020 Feb 3, J Cell BiolRead more
- c-Cbl Acts as an E3 Ligase Against DDA3 for Spindle Dynamics and Centriole Duplication during Mitosis. Gwon D et al., 2019 Dec 31, Mol CellsRead more
- Aurora B kinase activity is regulated by SET/TAF1 on Sgo2 at the inner centromere. Asai Y et al., 2019 Oct 7, J Cell BiolRead more