Hec1 antibody [9G3.23]
GTX70268
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
Product group Antibodies
TargetNDC80
Overview
- SupplierGeneTex
- Product NameHec1 antibody [9G3.23]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID9G3.23
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID10403
- Target nameNDC80
- Target descriptionNDC80 kinetochore complex component
- Target synonymsHEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80, kinetochore protein NDC80 homolog, NDC80 homolog, kinetochore complex component, NDC80 kinetochore complex component homolog, highly expressed in cancer protein, highly expressed in cancer, rich in leucine heptad repeats, kinetochore associated 2, kinetochore protein Hec1, kinetochore-associated protein 2, retinoblastoma-associated protein HEC
- HostMouse
- IsotypeIgG2a
- Protein IDO14777
- Protein NameKinetochore protein NDC80 homolog
- Scientific DescriptionThis gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Rahi A, Chakraborty M, Agarwal S, et al. The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore-microtubule coupling unit. J Cell Biol. 2023,222(8). doi: 10.1083/jcb.202208018Read this paper
- Zadra I, Jimenez-Delgado S, Anglada-Girotto M, et al. Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. Nat Commun. 2022,13(1):7147. doi: 10.1038/s41467-022-34909-yRead this paper
- Schrock MS, Scarberry L, Stromberg BR, et al. MKLP2 functions in early mitosis to ensure proper chromosome congression. J Cell Sci. 2022,135(12). doi: 10.1242/jcs.259560Read this paper
- Hong J, Gwon D, Jang CY. Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression. J Ginseng Res. 2022,46(3):481-488. doi: 10.1016/j.jgr.2021.11.004Read this paper
- Solon AL, Tan Z, Schutt KL, et al. Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Sci Adv. 2021,7(47):eabj9812. doi: 10.1126/sciadv.abj9812Read this paper
- Steblyanko Y, Rajendraprasad G, Osswald M, et al. Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins. EMBO J. 2020,39(23):e105432. doi: 10.15252/embj.2020105432Read this paper
- Yoshida S, Nishiyama S, Lister L, et al. Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Nat Commun. 2020,11(1):2652. doi: 10.1038/s41467-020-16488-yRead this paper
- Chuang SH, Lee YE, Huang LYL, et al. Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy. Eur J Med Chem. 2020,191:112118. doi: 10.1016/j.ejmech.2020.112118Read this paper
- Broad AJ, DeLuca KF, DeLuca JG. Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells. J Cell Biol. 2020,219(3). doi: 10.1083/jcb.201905144Read this paper
- Kim S, Kim NH, Park JE, et al. PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation. Nat Commun. 2020,11(1):612. doi: 10.1038/s41467-020-14511-wRead this paper
Datasheet
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