Hec1 antibody [9G3.23]
GTX70268
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
Product group Antibodies
TargetNDC80
Overview
- SupplierGeneTex
- Product NameHec1 antibody [9G3.23]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID9G3.23
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID10403
- Target nameNDC80
- Target descriptionNDC80 kinetochore complex component
- Target synonymsHEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80, kinetochore protein NDC80 homolog, NDC80 homolog, kinetochore complex component, NDC80 kinetochore complex component homolog, highly expressed in cancer protein, highly expressed in cancer, rich in leucine heptad repeats, kinetochore associated 2, kinetochore protein Hec1, kinetochore-associated protein 2, retinoblastoma-associated protein HEC
- HostMouse
- IsotypeIgG2a
- Protein IDO14777
- Protein NameKinetochore protein NDC80 homolog
- Scientific DescriptionThis gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore-microtubule coupling unit.Read more
- Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11.Read more
- MKLP2 functions in early mitosis to ensure proper chromosome congression.Read more
- Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression. Hong J et al., 2022 May, J Ginseng ResRead more
- Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Solon AL et al., 2021 Nov 19, Sci AdvRead more
- Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins. Steblyanko Y et al., 2020 Dec 1, EMBO JRead more
- Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Yoshida S et al., 2020 May 27, Nat CommunRead more
- Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy. Chuang SH et al., 2020 Apr 1, Eur J Med ChemRead more
- Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells. Broad AJ et al., 2020 Mar 2, J Cell BiolRead more
- PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation. Kim S et al., 2020 Jan 30, Nat CommunRead more


![WB analysis of (1) Jurkat, (2) HeLa, (3) NCCIT and (4) human spleen lysates (10 microg per lane) using HEC1 antibody [EPR5342] at a dilution of 1:10,000.](https://www.genetex.com/upload/website/prouct_img/normal/GTX63082/GTX63082_WB_w_23061202_241.webp)