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ProductsBack/Hec1 antibody [9G3.23]

Hec1 antibody [9G3.23]

GTX70268
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
DownloadDatasheet
Product group Antibodies
ReactivityHamster, Human, Mammals, Mouse
TargetNDC80
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Overview

  • Supplier
    GeneTex
  • Product Name
    Hec1 antibody [9G3.23]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    9G3.23
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10403
  • Target name
    NDC80
  • Target description
    NDC80 kinetochore complex component
  • Target synonyms
    HEC; HEC1; highly expressed in cancer protein; highly expressed in cancer, rich in leucine heptad repeats; HsHec1; hsNDC80; kinetochore associated 2; kinetochore protein Hec1; kinetochore protein NDC80 homolog; kinetochore-associated protein 2; KNTC2; NDC80 homolog, kinetochore complex component; NDC80 kinetochore complex component homolog; retinoblastoma-associated protein HEC; TID3
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDO14777
  • Protein Name
    Kinetochore protein NDC80 homolog
  • Scientific Description
    This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
  • Reactivity
    Hamster, Human, Mammals, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore-microtubule coupling unit.
    Read more
  • Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11.
    Read more
  • MKLP2 functions in early mitosis to ensure proper chromosome congression.
    Read more
  • Ginsenoside Rg1 suppresses cancer cell proliferation through perturbing mitotic progression. Hong J et al., 2022 May, J Ginseng Res
    Read more
  • Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Solon AL et al., 2021 Nov 19, Sci Adv
    Read more
  • Microtubule poleward flux in human cells is driven by the coordinated action of four kinesins. Steblyanko Y et al., 2020 Dec 1, EMBO J
    Read more
  • Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Yoshida S et al., 2020 May 27, Nat Commun
    Read more
  • Discovery of T-1101 tosylate as a first-in-class clinical candidate for Hec1/Nek2 inhibition in cancer therapy. Chuang SH et al., 2020 Apr 1, Eur J Med Chem
    Read more
  • Aurora B kinase is recruited to multiple discrete kinetochore and centromere regions in human cells. Broad AJ et al., 2020 Mar 2, J Cell Biol
    Read more
  • PRMT6-mediated H3R2me2a guides Aurora B to chromosome arms for proper chromosome segregation. Kim S et al., 2020 Jan 30, Nat Commun
    Read more