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ProductsBack/Luteolin [491-70-3]
Chemical Structure
Chemical Structure
Chemical Structure

Luteolin [491-70-3]

Research Use Only
AG-CN2-0098
AdipoGen Life Sciences
CAS Number491-70-3
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight286.2
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Luteolin
  • Delivery Days Customer
    10
  • CAS Number
    491-70-3
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C15H10O6
  • Molecular Weight
    286.2
  • Scientific Description
    Anticancer and antimetastatic agent that induces apoptosis and modulates autophagy. Shown to inhibits kinase signalling, including PKC(epsilon) and Src kinase, HDAC, Phosphatidylinositol 3-kinase (PI3K) / Akt and p90 ribosomal S6 kinase (RSK1/RSK2). Topoisomerase I Inhibitor. Anti-inflammatory agent that inhibits 15-Lipoxygenase (15-LOX) and IL-6 production. Antioxidant. Free radical scavenger. Antiadipogenic agent, that inhibits PPAR-gamma, fatty acid synthase (FAS) and alpha-Glucosidase. Neuroprotective. Monoamine transporter activator and inhibitor of phosphodiesterases 1-5 (PDE1-5). Shown to selectively inhibits chymotrypsin-like and trypsin-like proteasome catalytic activity. - Chemical. CAS: 491-70-3. Formula: C15H10O6. MW: 286.2. Synthetic. Anticancer and antimetastatic. alpha-Glucosidase inhibitor. Topoisomerase I Inhibitor. Apoptosis inducer. Anti-inflammatory. 15-Lipoxygenase (15-LOX) inhibitor. IL-6 production inhibitor. Fatty acid synthase (FAS) inhibitor. Antioxidant. Free radical scavenger. Antiadipogenic. PPAR-gamma inhibitor. Neuroprotective. Monoamine transporter activator. Inhibitor of phosphodiesterases 1-5 (PDE1-5). PKC(epsilon) and Src kinase inhibitor. HDAC inhibitor. Autophagy modulator Phosphatidylinositol 3-kinase (PI3K) / Akt signaling inhibitor. p90 ribosomal S6 kinase (RSK1/RSK2) kinase activity inhibitor.
  • SMILES
    OC1=CC(O)=C2C(=O)C=C(OC2=C1)C1=CC=C(O)C(O)=C1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Effects of luteolin and quercetin, inhibitors of tyrosine kinase, on cell growth and metastasis-associated properties in A431 cells overexpressing epidermal growth factor receptor: Y.T. Huang, et al.; Br. J. Pharmacol. 128, 999 (1999)
  • Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid: J.S. Kim, et al.; Biosci. Biotechnol. Biochem. 64, 2458 (2000)
  • Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I: A.R. Chowdhury, et al.; Biochem. J. 366, 653 (2002)
  • Inhibition of matrix-proteases by polyphenols: Chemical insights for anti-inflammatory and anti-invasion drug design: L. Sartor, et al.; Biochem. Pharmacol. 64, 229 (2002)
  • Luteolin inhibits the nuclear factor-kappa B transcriptional activity in Rat-1 fibroblasts: S.H. Kim, et al.; Biochem. Pharmacol. 66, 955 (2003)
  • Inhibition of 15-lipoxygenases by flavonoids: Structure-activity relations and mode of action: C.D. Sadik, et al.; Biochem. Pharmacol. 65, 773 (2003)
  • Induction of apoptosis by luteolin through cleavage of Bcl-2 family in human leukemia HL-60 cells: A.C. Cheng, et al.; Eur. J. Pharmacol. 509, 1 (2005)
  • Luteolin inhibits insulin-like growth factor 1 receptor signaling in prostate cancer cells: J. Fang, et al.; Carcinogenesis 28, 713 (2007)
  • Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1: S. Jang, et al.; PNAS 105, 7534 (2008)
  • Inhibition of fatty acid synthase by luteolin post-transcriptionally down-regulates c-Met expression independent of proteosomal/lysosomal degradation: D.T. Coleman, et al.; Mol. Cancer Ther. 8, 214 (2009)