IHC-P analysis of colorectal carcinoma tissue using GTX01906 MLH1 antibody [ES05]. Note nuclear staining in a high proportion of the malignant cells.
IHC-P analysis of colorectal carcinoma tissue using GTX01906 MLH1 antibody [ES05]. Note nuclear staining in a high proportion of the malignant cells.
MLH1 antibody [ES05]
GTX01906
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetMLH1
Overview
- SupplierGeneTex
- Product NameMLH1 antibody [ES05]
- Delivery Days Customer9
- Application Supplier NoteIHC-P: 1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDES05
- ConjugateUnconjugated
- Gene ID4292
- Target nameMLH1
- Target descriptionmutL homolog 1
- Target synonymsCOCA2; DNA mismatch repair protein Mlh1; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1; mutL homolog 1, colon cancer, nonpolyposis type 2
- HostMouse
- IsotypeIgG1
- Protein IDP40692
- Protein NameDNA mismatch repair protein Mlh1
- Scientific DescriptionThe protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203