MLKL antibody [8H7]

GeneTex

MLKL antibody [8H7]

9

IHC-P: 1:100-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

8H7

1 mg/ml

Unconjugated

MLKL

mixed lineage kinase domain like pseudokinase

hMLKL; mixed lineage kinase domain-like protein

Mouse

IgG1

Mixed lineage kinase domain-like protein

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

Human

-20°C or -80°C,2°C to 8°C

12352203