Western blot analysis of extracts from NIH-3T3 cells treated with TNF using IKK- alpha/ beta (Phospho-Ser176/177) antibody.The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from NIH-3T3 cells treated with TNF using IKK- alpha/ beta (Phospho-Ser176/177) antibody.The lane on the right is treated with the antigen-specific peptide.
Phospho-CHUK/IKBKB (Ser176/177) Antibody
CSB-PA983649
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCHUK
Overview
- SupplierCusabio
- Product NamePhospho-CHUK/IKBKB (Ser176/177) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID1147
- Target nameCHUK
- Target descriptioncomponent of inhibitor of nuclear factor kappa B kinase complex
- Target synonymsBPS2; conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; I-kappa-B kinase-alpha; IkB kinase alpha subunit; IKBKA; IKK1; IKKA; IKK-a kinase; IKK-alpha; inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; Nuclear factor NFkappaB inhibitor kinase alpha; TCF16; TCF-16; transcription factor 16
- HostRabbit
- IsotypeIgG
- Protein IDO15111
- Protein NameInhibitor of nuclear factor kappa-B kinase subunit alpha
- Scientific DescriptionActs as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Chandrakesan P, et al. (2010)J Biol Chem 285, 33485-98 Hinz M, et al. (2010Mol Cell 40, 63-74 Choudhary S, Lu M, Cui R, Brasier AR (2007)Mol Endocrinol 21, 2203-17
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203