Phospho-CHUK/IKBKB (Ser176/177) Antibody

Cusabio

Phospho-CHUK/IKBKB (Ser176/177) Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

CHUK

component of inhibitor of nuclear factor kappa B kinase complex

BPS2, IKBKA, IKK-1, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, inhibitor of nuclear factor kappa-B kinase subunit alpha, I-kappa-B kinase 1, I-kappa-B kinase-alpha, IKK-a kinase, IkB kinase alpha subunit, Nuclear factor NFkappaB inhibitor kinase alpha, conserved helix-loop-helix ubiquitous kinase, transcription factor 16

Rabbit

IgG

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Chandrakesan P, et al. (2010)J Biol Chem 285, 33485-98 Hinz M, et al. (2010Mol Cell 40, 63-74 Choudhary S, Lu M, Cui R, Brasier AR (2007)Mol Endocrinol 21, 2203-17

Human, Mouse, Rat

-20°C or -80°C

41116161