ProductsBack/RIP antibody

RIP antibody

Name: RIP antibody
SKU: GTX111074_G10
Availability: BackOrder

GTX111074

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry

DownloadDatasheet

Product group Antibodies

TargetRIPK1

Overview

Supplier
GeneTex
Product Name
RIP antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID8737
Target name
RIPK1
Target description
receptor interacting serine/threonine kinase 1
Target synonyms
AIEFL; cell death protein RIP; IMD57; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP1; RIP-1; serine/threonine-protein kinase RIP
Host
Rabbit
Isotype
IgG
Protein IDQ13546
Protein Name
Receptor-interacting serine/threonine-protein kinase 1
Scientific Description
Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via Lys-63-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Lanzillotta C et al., 2021 Jan, Prog Neurobiol
Read more
Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo. Chen YH et al., 2020, Cancer Manag Res
Read more
Subendothelial matrix components influence endothelial cell apoptosis in vitro. Saemisch M et al., 2019 Feb 1, Am J Physiol Cell Physiol
Read more
3D matrix-embedding inhibits cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis of human endothelial cells. Saemisch M et al., 2018 Apr, J Tissue Eng Regen Med
Read more
DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells. Tsui KH et al., 2017 Aug, Reproduction
Read more
Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells. Lin CY et al., 2016, Cell Death Discov
Read more
Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Li CJ et al., 2015 Apr 24, Sci Rep
Read more

RIP antibody

Large volume orders?

Overview

References

Related products