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ProductsBack/RIP antibody

RIP antibody

Research Use Only
GTX111074
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetRIPK1
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Overview

  • Supplier
    GeneTex
  • Product Name
    RIP antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:1000-1:10000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Formulation
    Liquid
  • Gene ID8737
  • Target name
    RIPK1
  • Target description
    receptor interacting serine/threonine kinase 1
  • Target synonyms
    AIEFL; cell death protein RIP; IMD57; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP1; RIP-1; serine/threonine-protein kinase RIP
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13546
  • Protein Name
    Receptor-interacting serine/threonine-protein kinase 1
  • Scientific Description
    Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via Lys-63-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Lanzillotta C et al., 2021 Jan, Prog Neurobiol
    Read more
  • Synergistic Anticancer Effects of Gemcitabine with Pitavastatin on Pancreatic Cancer Cell Line MIA PaCa-2 in vitro and in vivo. Chen YH et al., 2020, Cancer Manag Res
    Read more
  • Subendothelial matrix components influence endothelial cell apoptosis in vitro. Saemisch M et al., 2019 Feb 1, Am J Physiol Cell Physiol
    Read more
  • 3D matrix-embedding inhibits cycloheximide-mediated sensitization to TNF-alpha-induced apoptosis of human endothelial cells. Saemisch M et al., 2018 Apr, J Tissue Eng Regen Med
    Read more
  • DHEA protects mitochondria against dual modes of apoptosis and necroptosis in human granulosa HO23 cells. Tsui KH et al., 2017 Aug, Reproduction
    Read more
  • Simultaneous induction of apoptosis and necroptosis by Tanshinone IIA in human hepatocellular carcinoma HepG2 cells. Lin CY et al., 2016, Cell Death Discov
    Read more
  • Synergistic protection of N-acetylcysteine and ascorbic acid 2-phosphate on human mesenchymal stem cells against mitoptosis, necroptosis and apoptosis. Li CJ et al., 2015 Apr 24, Sci Rep
    Read more