TNF alpha antibody

GeneTex

TNF alpha antibody

9

This antibody is primarily against mature TNF alpha protein and does not recognize human TNG-beta (lymphotoxin).

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TNF

tumor necrosis factor

APC1 protein; DIF; TNF, macrophage-derived; TNF, monocyte-derived; TNFA; TNF-a; TNF-alpha; TNFSF2; TNLG1F; tumor necrosis factor; tumor necrosis factor ligand 1F; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha

Rabbit

IgG

Tumor necrosis factor-alpha (TNF-a), also known as cachectin, is an inflammatory. TNF-a is produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, Astrocytes, endothelial cells, smooth muscle cells and some transformed cells. TNF-a appears to be a major mediator of inflammatory responses and overproduction results in the extensive tissue damage associated with endotoxemia and cachexia. In addition, high serum levels of TNF are associated with septic shock, rejection of renal transplants, parasitic infections and various neoplastic diseases. TNF-a influences the growth and function of both normal and neoplastic cells. On normal cells, TNF-a exhibits growth enhancing activities for fibroblasts, T cells and B cells; differentiation of myeloid cells. On neoplastic cells, TNF-a exerts growth inhibitory activities that can be either cytostatic or cytotoxic.

Human

2°C to 8°C,-20°C or -80°C

12352203