Astragaloside IV [84687-43-4]

Chemodex

Astragaloside IV [84687-43-4]

10

84687-43-4

Research Use Only

>98%

Non-hazardous

C41H68O14

784.98

Astragaloside IV (AS-IV) is a bioactive saponin and constituent of the traditional chinese medicine plant Astragali radix. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antioxidative, anti-asthma, antidiabetes, anticancer, immunoregulation, neuroprotective and cardioprotective properties via numerous signaling pathways. This includes inhibition of NF-kappaB, inducing hypoxia-inducible factor-1alpha accumulation via PI3K/Akt pathway, reducing Abeta production in Alzheimers disease through inhibition of BACE1, working as a natural PPARgamma agonist, improving lipid metabolism in obese mice, enhancing chemosensitivity through CD276 (B7-H3)-pathway inhibition, and suppressing glucose-induced NLRP3 inflammasome activation. - Chemical. CAS: 84687-43-4. Formula: C41H68O14. MW: 784.98. Astragaloside IV (AS-IV) is a bioactive saponin and constituent of the traditional chinese medicine plant Astragali radix. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antioxidative, anti-asthma, antidiabetes, anticancer, immunoregulation, neuroprotective and cardioprotective properties via numerous signaling pathways. This includes inhibition of NF-kappaB, inducing hypoxia-inducible factor-1alpha accumulation via PI3K/Akt pathway, reducing Abeta production in Alzheimers disease through inhibition of BACE1, working as a natural PPARgamma agonist, improving lipid metabolism in obese mice, enhancing chemosensitivity through B7-H3 inhibition, and suppressing glucose-induced NLRP3 inflammasome activation.

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2°C to 8°C,-20°C

12352200