ZO-1 antibody [HL3114]

GeneTex

ZO-1 antibody [HL3114]

7

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Monoclonal

HL3114

1 mg/ml

Unconjugated

TJP1

tight junction protein 1

tight junction protein ZO-1; ZO-1; zona occludens 1; zonula occludens 1 protein

Rabbit

IgG

Tight junction protein ZO-1

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Human, Mouse, Rat

-20°C or -80°C,2°C to 8°C

12352203