ICC/IF analysis of paraformaldehyde fixed A431 cells using GTX88275 ZO-1 antibody, Internal. Green : Primary antibody Blue : DAPI Negative control: Unimmunized goat IgG Dilution : 10microg/ml
ICC/IF analysis of paraformaldehyde fixed A431 cells using GTX88275 ZO-1 antibody, Internal. Green : Primary antibody Blue : DAPI Negative control: Unimmunized goat IgG Dilution : 10microg/ml
ZO-1 antibody, Internal
GTX88275
ApplicationsImmunoFluorescence, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetTJP1
Overview
- SupplierGeneTex
- Product NameZO-1 antibody, Internal
- Delivery Days Customer7
- Antibody SpecificityThis antibody is expected to recognize both reported isoforms (NP_003248.3; NP_783297.2)
- ApplicationsImmunoFluorescence, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.50 mg/ml
- ConjugateUnconjugated
- Gene ID7082
- Target nameTJP1
- Target descriptiontight junction protein 1
- Target synonymstight junction protein ZO-1; ZO-1; zona occludens 1; zonula occludens 1 protein
- HostGoat
- IsotypeIgG
- Protein IDQ07157
- Protein NameTight junction protein ZO-1
- Scientific DescriptionThis gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203