Anti-CD51 [NKI-M9]

Absolute Antibody

Anti-CD51 [NKI-M9]

7

This antibody is specific for human CD51. CD51 is a receptor for vitronectin. It recognizes the sequence R-G-D in a wide array of ligands.

To study MSCs as a promising therapeutic agents for a variety of diseases, flow cytometry was performed on human MSCs using the mouse version of this antibody (Wang et al, 2015; pmid:26148841). To study how Bordetella pertussis enters respiratory epithelial cells, an invasion assay was performed using the mouse version of this antibody on human lung epithelial cell line A549 with Bordetella pertussis (Ishibashi et al, 2001; pmid:11373122). To find surface markers specific for Nestin+ cells, flow cytometry was performed on mouse BM primary cells using the mouse version of this antibody. Furthermore, human foetal bones and HA/TCP grafts were stained using this antibody (Pinho et al, 2013; pmid:23776077). To investigate the developmental pathway for human megakaryocytes, flow cytometry was performed on BM HSPCs from healthy donors using the mouse version of this antibody (Miyawaki et al, 2017; pmid:28336526). To determine if OCs express other membrane receptors for matrix proteins, immunohistochemistry was performed on human joint revision capsule tissue using the mouse version of this antibody (Quinn et al, 1991; pmid:1717412).

Functional Assay, Flow Cytometry, ImmunoHistoChemistry

FC; functional assay; IHC

Research Use Only

Monoclonal

NKI-M9

ITGAV

integrin subunit alpha V

antigen identified by monoclonal antibody L230; CD51; integrin alpha-V; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); MSK8; vitronectin receptor subunit alpha; VNRA; VTNR

Human

IgG1

Integrin alpha-V

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format for improved compatibility with existing reagents assays and techniques.

Human, Mouse

Human, Mouse

The mouse version of this antibody was raised by immunizing a BALB/c mouse with cultured melanoma cells derived from a human melanoma metastasis.

-20°C,2°C to 8°C

12352203